SiPore® Technology

Advancing Metabolic Health Through a Unique Mode of Action

Sigrid Therapeutics is at the forefront of metabolic health innovation with SiPore®, a patented platform technology designed to slow digestion. By leveraging precisely engineered bioengineered silica particles, SiPore® provides a non-pharmaceutical approach to controlling blood sugar levels, supporting healthy weight management, and improving overall metabolic function.

With over 15 years of research, 10+ patents, and four clinical trials, SiPore® represents a scientifically validated and scalable solution to address the growing global burden of metabolic diseases, including prediabetes, type 2 diabetes, and obesity.

Mechanism of Action: Slowing Digestion for Metabolic Stability

Precision-Engineered Silica for Controlled Digestion

SiPore® technology consists of micron-sized porous silica particles that operate locally in the gut. These particles are designed to physically entrap a fraction of digestive enzymes, slowing the breakdown of carbohydrates and fats. This controlled digestion process leads to:

  • Reduced postprandial glucose and lipid spikes

  • More gradual energy release from food

  • Lower caloric absorption from fats and carbohydrates

SiPore® functions entirely within the gastrointestinal tract, without entering the bloodstream, ensuring an exceptional safety and tolerability profile.

A Versatile Platform for Multiple Industries

SiPore® is a scalable technology with applications across several high-growth industries. Currently, three business verticals are in commercialization, with four additional expansion areas under development.

Metabolic Health

Medical Treatment – SiPore® is the active technology in Carb Fence™, a medical food designed for blood sugar and weight management in prediabetes, type 2 diabetes, and obesity.

Dietary Supplements – SiPore® powers Glucose Stabiliser, a supplement supporting metabolic health in a consumer-friendly format.

Food Additives – SiPore® can be integrated into functional foods to provide measurable health benefits without altering taste or texture.

Oral Health

SiPore® technology is being explored in both consumer and professional oral care products, with a focus on reducing harmful bacterial growth and limiting dental caries formation.

Veterinary

SiPore® technology is being explored in both consumer and professional oral care products, with a focus on reducing harmful bacterial growth and limiting dental caries formation.

“SiPore® is designed with safety and sustainability in mind. It is made of pure silica, a natural mineral made of silicon and oxygen, two of the earth’s most abundant elements. SiPore® derives its function from its unique architecture and chemistry. It is gentle to the human body as to the environment.”

— Eric Johnston, CTO & COO

Market-Ready Solutions: From Research to Commercialization

Sigrid Therapeutics has successfully transitioned SiPore® from laboratory innovation to market reality, with two products now in commercialization:

Carb Fence™ – A medical-grade liquid formula for prediabetic, diabetic, and obese individuals, designed to reduce blood sugar, manage a healthy weight and support broad metabolic function.

Glucose Stabiliser – A dietary supplement capsules aimed at individuals seeking daily metabolic support for blood sugar and weight management. Available in Sweden and the U.S. through our dedicated DTC e-com store.